ABSTRACT
Policosanol is a natural mixture of higher primary aliphatic alcohols isolated and purified from sugar cane (Saccharum officinarum, L.) wax, whose main component is octacosanol. Policosanol (5-200 mg/kg) orally administered for 4 weeks to normocholesterolemic New Zealand rabbits significantly reduced total cholesterol and low density lipoprotein cholesterol (LDL-C) serum levels in a dose dependent manner. Serum triglyceride levels of treated and control animals were significantly different, but the reduction observed was not dose-dependent. High density lipoprotein cholesterol (HDL-C) levels remained unchanged. Results indicate that the reduction in total cholesterol values induced by policosanol is mainly mediated through a decrease in LDL-C levels
Subject(s)
Animals , Rabbits , Anticholesteremic Agents/pharmacology , Cholesterol/blood , Fatty Alcohols/pharmacology , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Dose-Response Relationship, Drug , Triglycerides/bloodABSTRACT
En este trabajo se estudio el efecto de la administración oral de Policosanol (mezcla de alcoholes de alto molecular cuyo componente fundamental es el octacosanol) sobre los lípidos y lipoproteínas séricos de conejos Nueva Zelanda normocolesterolémicos. El tratamiento oral con Policosanol (5 mg/kg/día) durante 4 semanas provocó una disminución significativa de los niveles séricos de colesterol, triglicéridos y LDL-C, sin producir cambios significativos en los valores de HDL-. El contenido de colesterol hepático de los animales tratados resultó significativamente menor que el de los controles